Psilocybin molecule:

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Psilocybin Clinical Trials


Characterization of Altered Waking States of Consciousness in Healthy Humans


To see complete record on clinicaltrials.gov, please visit this link

Id: NCT03853577

Organisation Name: University of Zurich

Overal Status: Active, not recruiting

Start Date: July 8, 2020

Last Update: November 6, 2020

Lead Sponsor: University of Zurich

Brief Summary: Altered waking states of consciousness and its underlying functional organization have gained increasing interest in recent years, i.e. in identifying the neural basis of consciousness. To overcome fundamental shortcomings of current methods to objectively assess the level of consciousness, the investigators propose here to apply a novel and empirically validated measure called 'perturbational complexity index' (PCI) based on the integrated information theory (IIT). This involves a combination of transcranial magnetic stimulation (TMS) and highdensity electroencephalography (hd-EEG) to measure electrocortical responses as distributed cerebral interactions ('integration') and spatiotemporal pattern ('information'). Given the finding of subjectively expanded consciousness as induced here by psilocybin, the investigators hypothesize that the PCI may be higher in such states. This will be the first TMS/hd-EEG study to investigate quantitatively the level of consciousness in a pharmacologically altered waking state of consciousness.

Conditions:
  • Altered Waking States of Consciousness in Healthy Humans


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