Psilocybin molecule:

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Psilocybin Clinical Trials


Psilocybin-facilitated Treatment for Cocaine Use: A Pilot Study


To see complete record on clinicaltrials.gov, please visit this link

Id: NCT02037126

Organisation Name: University of Alabama at Birmingham

Overal Status: Recruiting

Start Date: May 2015

Last Update: November 23, 2020

Lead Sponsor: University of Alabama at Birmingham

Brief Summary: The primary purpose of this study is to evaluate the feasibility and estimate the efficacy of psilocybin-facilitated treatment for cocaine use. We also will monitor the impact of psilocybin-facilitated treatment on the use of other drugs and outcomes relevant to cocaine involvement (e.g., criminal involvement).

MRI assessment is a unique aspect of this study. As a potential biological mechanism of psilocybin's effect includes changes in default mode network functional connectivity (Carhart-Harris et al., 2012), we will determine if psilocybin's therapeutic effects are mediated by such changes. Moreover, as Glx (a brain metabolite that reflects glutamate) abnormalities have been shown to play a role in cocaine addiction, we will determine if psilocybin impacts Glx in the anterior cingulate cortex and hippocampus.

Conditions:
  • Cocaine-Related Disorders


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