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Mdma Clinical Trials

Interactions between 3,4-methylenedioxymethamphetamine (MDMA or ’ecstasy’) and Ä9-tetrahydrocannabinol (THC or ‘marihuana’) in humans

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Id: NTR1317

Organisation Name: ZonMw

Overal Status: Inclusion stopped, follow up

Start Date: 2006-06-01

Lead Sponsor: ZonMw

Brief Summary: Ecstasy or (±) 3,4-methylenedioxymethamphetamine (MDMA) is widely used as a recreational drug. Its acute adverse effects include mental confusion, neurological-, motor effects and cardiovascular disturbances. MDMA is often used in combination with other substances of abuse, notably alcohol and/or cannabis (active compound; THC) and is also taken at rave parties in circumstances of intense exercise and high ambient temperature. This may result in even more serious and unpredictable adverse events, but basic knowledge is lacking on these interactions. The main objective of the present experiment is to investigate to what extent acute effects of MDMA on heart rate, blood pressure, body temperature and cognitive function are influenced by co-exposure to THC (i.e., delta-9-tetrahydrocannabinol). In order to address this question, we will perform a double blind placebo controlled experiment in a group of 16 regular users of ecstasy and cannabis. The results of this exploratory study will provide details on how these substances are likely to interact to produce unwanted effects on human behaviour, physiology and biochemistry. This will lead to evidence-based information for adequate and effective prevention, and guidance for more appropriate aid in case of medical emergencies resulting from side effects.

Country: Netherlands