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Mdma Clinical Trials

MDMA (3,4-methylenedioxy-N-methylamphetamine) and tinnitus

To see complete record on anzctr.org.au, please visit this link

Id: ACTRN12613000685718

Organisation Name: The University of Auckland Research Faculty

Overal Status: Completed

Start Date: 19/08/2013

Brief Summary: MDMA has recently become a focus of research for its possible therapeutic effects. Tinnitus is the perception of sound(s) in the ear(s) or head without an external source. There is currently no drug therapy for tinnitus. There are a growing number of studies showing that MDMA can improve the outcome of psychotherapy in patients with posttraumatic stress disorder (PTSD). PTSD is associated with abnormal activity in brain regions associated with memory and learning (hippocampus and prefrontal cortex) and fear (amygdala). MDMA tends to normalize the activity within these regions and improve the PTSD symptoms. Recent studies indicate that tinnitus is associated with a similar pattern of abnormal brain activity that is found in patients with PTSD. It is therefore possible that MDMA may also help patients with tinnitus. There is also anecdotal evidence supporting this idea. Some tinnitus patients report a significant reduction or an absence of tinnitus after use of Ecstasy. This study is to investigate whether administration of a single dose of MDMA will decrease tinnitus perception.

• New Zealand