LSD molecule:

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LSD Clinical Trials

LSD Base and LSD Tartrate Bioequivalence and Bioavailability in Healthy Subjects

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Id: NCT04865653

Organisation Name: University Hospital, Basel, Switzerland

Overal Status: Recruiting

Start Date: March 17, 2022

Last Update: March 31, 2022

Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary: Lysergic acid diethylamide (LSD) is used as recreational substance and as a research substance to study the mind. Recreationally, LSD is typically used in the form of "blotters" containing LSD tartrate. In research, both LSD base (LSD alone) or LSD salt in the form of LSD tartrate are used. The oral bioavailability of LSD is not known and LSD alone and LSD as salt have never been directly compared regarding their equivalence of plasma concentrations and effects. Because different forms of LSD are used in research it is important to know their difference or equivalence for correct dosing of LSD. The present study will compare equivalent doses of LSD base in ethanol orally, LSD tartrate in water administered orally, LSD base in an orodispersible film administered orally and LSD tartrate in water administered intravenously, as well as a placebo using a double-blind, randomized, counterballanced cross-over design in healthy participants.

  • Healthy

Total execution time in seconds: 0.20288801193237