Lysergicaciddiethylamide molecule:

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Lysergic acid diethylamide Clinical Trials

LSD microdosing - A repeated dosing study

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Id: NL8736

Organisation Name: Maastricht University Department of Psychology and Neurosciences

Overal Status: Open for patient inclusion

Start Date: 2020-02-03

Lead Sponsor: Maastricht University Department of Psychology and Neurosciences

Brief Summary: LSD is a psychedelic substance that is used recreationally because of its effects on consciousness. More specifically, LSD induces acute transient alterations in waking consciousness including visual perceptual alterations, audio-visual synesthesia, derealization and depersonalization. Modern experimental studies documented marked changes in perception at a moderate (100 µg orally or 75 µg intravenously) or high 200 µg oral dose of LSD in healthy volunteers. Recently, repeated use of low doses of LSD as so-called LSD microdosing to enhance mood, creativity, and/or performance has been observed. However, the subjective and cognitive effects of repeatedly consuming such low doses (between 5 to 20 µg) have not yet been studied in modern studies using validated psychometric tools. In our recent dose-finding study it is shown that positive effects on mood and cognition are evident in 10 micrograms of LSD and clearly visible in 20 micrograms. However, it is unclear what the acute and sub-acute effects are of a repeated microdosing schedule for four weeks.

Country: Netherlands

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