Ketamine molecule:

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Ketamine Clinical Trials


Reversal of opioid-induced respiratory depression (OIRD) by ketamine in healthy volunteers


To see complete record on www.trialregister.nl, please visit this link

Id: NTR6248

Organisation Name: LUMC

Overal Status: Open for patient inclusion

Start Date: 2016-10-21

Lead Sponsor: LUMC

Brief Summary: This is a trial with a prospective double blind, placebo controlled, crossover design in healthy volunteers. The subjects will receive an intravenous infusion of remifentanil and isohypercapnic ventilation (that is ventilation at an elevated and clamped end-tidal PCO2 aimed to increase ventilation to 20 ± 2 L/min) will be measured using a facemask.

Intravenous remifentanil will be administered by target-controlled infusion (TCI), aimed at reducing isohypercapnic ventilation by 50%. After ventilation has reached a steady state, subjects will be randomized to step wise increases in S-ketamine or placebo infusions. The S-ketamine infusion is aimed at restoring ventilation to the baseline value (± 10%). If the baseline value is reached no further infusions are given.

On a separate occasion, we will assess the effect of ketamine on respiration by
performing the step-wise increases in ketamine but without the remifentanil and
without CO2 clamping.

Country: Netherlands



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