Ketamine molecule:

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Ketamine Clinical Trials


The effect of ketamine and methadon on healthy volunteers with special focus on painscore, sedation, ventilatory depression and change of pupil diameter.


To see complete record on www.trialregister.nl, please visit this link

Id: NTR2039

Organisation Name: Leiden University Medical Centre (LUMC)

Overal Status: Planned

Start Date: 2010-01-02

Lead Sponsor: Leiden University Medical Centre (LUMC)

Brief Summary: In this double blinded, placebo-controlled crossover trial, the effect
of mu opioid receptor (MOR) versus N-methyl-D-aspartate (NMDAR) receptor
involvement in ketamine and methadone will be studied in healthy
volunteers. 48 Volunteers will receive either a ketamine or a methode
infusion and a concomitant placebo or naloxone infusion on two different
occasions. Volunteers will be in the respiratory leg or in the analgesia
leg of the study. Respiratory measurements by means of the dynamic
end-tidal forcing technique or VAS-score upon heatpain and pupil
diameter will be assessed regularly throughout the study in order to
obtain information on MOR- or NMDAR-involvement.

Country: Netherlands



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