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Ketamine Clinical Trials

Ketamine as the Main Analgesic Agent During Analgesia-based Sedation for Elective Colonoscopy- a Randomised, Double-blind, Control Study

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Id: NCT05421962

Organisation Name: Cantonal Hospital Zenica

Overal Status: Completed

Start Date: January 1, 2020

Last Update: June 21, 2022

Lead Sponsor: Cantonal Hospital Zenica

Brief Summary: Aim: The aim of the study was to to compare the analgesic effects of ketamine over fentanyl combined with propofol in analgesia-based elective colonoscopy with purpose of patient safety and satisfaction.

Methods: This is a double-blinded prospective randomized controlled trial. Ninety patients were included and randomized to either fentanyl-propofol (Group FP, n: 30), ketamine-propofol (Group KP, n: 30) or propofol-control group (Group C, n: 30). Group FP patients received fentanyl and propofol, Group KP received ketamine and propofol and Group C, propofol. In all groups, incremental doses of propofol were used to maintain a Ramsay sedation score (RSS) of 5. Respiratory depression, hemodynamic parameters were monitored for the first minute and every 5 minutes during endoscopy. Fifteen minutes after the procedure, the degree of pain was assessed using a visual analog scale (VAS), the quality of recovery according to the Aldrete score (ARS), complications during and after the procedure and additional doses of propofol were recorded.

  • Pain
  • Side Effect

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