Ketamine molecule:

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Ketamine Clinical Trials

Comparison of Esketamine and Sevoflurane on Emergence Agitation for Pediatric Ophthalmological Procedure

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Id: NCT05321160

Organisation Name: Eye & ENT Hospital of Fudan University

Overal Status: Recruiting

Start Date: March 10, 2021

Last Update: December 6, 2022

Lead Sponsor: Eye & ENT Hospital of Fudan University

Brief Summary: Emergence agitation is the most common reason for post-anesthesia care unit delay. Sevoflurane is used frequently inhalational anaesthetic agent to provide pediatric anaesthesia because of the nonirritant nature. It has been successfully used for keeping spontaneous breathing without tracheal intubation. However, sevoflurane may cause emergence agitation as the incidence varied from 10%-80%. Although there are many sedative agents to reduce its incidence, such as propofol, midazolam, a2 adrenergic receptor agonists and ketamine, the efficacy remains limited.

Ketamine, a neuroleptic anesthetic agent, contains two optical isomers, s(+)-ketamine (esketamine) and R(-)-ketamine. Esketamine is a right-handed split of ketamine, which has enhanced analgesic potency and lower incidence of psychotropic side effects compared to ketamine. It stimulate breathing due to N-Methyl-D-Aspartate receptor blockade, and could even effectively countered remifentanil-induced respiratory depression. The investigators compared the effectiveness of esketamine and sevoflurane in reducing the incidence of emergence agitation after painless ophthalmological procedure in pediatric patients.

  • Emergence Agitation

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