Ketamine Clinical Trials
A Randomized Control Trial Employing fMRI to Investigate the Effects of Ketamine on Mentalizing and Metacognition in Healthy Volunteers
To see complete record on clinicaltrials.gov, please visit this link
Id: NCT05320991
Organisation Name: University Hospital, Bonn
Overal Status: Completed
Start Date: June 15, 2019
Last Update: April 18, 2022
Lead Sponsor: University Hospital, Bonn
Brief Summary: Antipsychotic medication shows generally good effect sizes when looking at reduction of positive psychotic symptoms of schizophrenia, such as paranoia or delusion. However, social functioning often remains deficient in patients, meaning dopamine-receptor antagonists are not sufficient in treatment of people with schizophrenia.
A naturalistic video-based paradigm, named MASC has been used in the past to model over- and undermentalizing in patients with autism spectrum disorder and schizophrenia, since deficits in mentalizing can be explained by either overinterpreting a social situation (e.g. paranoid thoughts about intentions of others towards self) or by lacking the skill to read intentions of others.
To find out whether experimental manipulation via a non-competetive N-methyl-D-aspartate antagonist can induce difficulties with social cognition similar to those observed in people with schizophrenia, the investigators will conduct a RCT applying either ketamine or a placebo intravenously while participants are completing the above mentioned mentalizing task in the fMRI-scanner.
Conditions:
- Ketamine-Induced Psychotic Disorder
- Social Cognition
- Theory of Mind
Total execution time in seconds: 0.53024411201477