Ketamine molecule:

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Ketamine Clinical Trials

Analgesic Effect of Intraoperative Intravenous S-Ketamine During Total Knee Arthroplasty Surgery:A Randomized Controlled Clinical Trial

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Id: NCT05289050

Organisation Name: Qianfoshan Hospital

Overal Status: Recruiting

Start Date: April 19, 2022

Last Update: December 13, 2022

Lead Sponsor: Ling Dong

Brief Summary: Severe acute pain after total knee arthroplasty surgery has multiple implications for hospitals and patients, monopolising resources and affecting the quality of life. S-ketamine inhibits N-methyl-d-aspartate (NMDA) receptor activation and attenuates central sensitization associated with hyperalgesia, opioid tolerance.Therefore, the primary aim of this trial was to investigate whether s-ketamine decreases pain and opioid consumption postoperatively in adult individuals undergoing total knee arthroplasty surgery.

  • Postoperative Pain, Acute
  • Anaesthetic

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