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Ketamine Clinical Trials

Second Affiliated Hospital Zhejiang University School of Medicine

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Id: NCT05016128

Organisation Name: Second Affiliated Hospital, School of Medicine, Zhejiang University

Overal Status: Recruiting

Start Date: August 17, 2021

Last Update: September 29, 2021

Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Brief Summary: Postoperative hyperalgesia (POH) is a paradoxical clinical state of increased sensation of pain or increased sensitivity to non-painful stimuli at the site of surgery or at a surrounding area that was not directly injured. Opioid-induced hyperalgesia (OIH) and nociceptive-induced hyperalgesia (NIH) are the two main causes of POH.N-methyl-D-aspartate receptor (NMDAR) activation plays a central role in the development of POH.S-ketamine,which is a NMDA-receptor antagonist,has been on the market in china since 2019.The aim of this study is to evaluate the effects of S-ketamine on POH and chronic postoperative pain after video-assisted thoracic surgery.

  • Postoperative Hyperalgesia

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