Ketamine molecule:

Image from PubChem

Ketamine Clinical Trials

Comparison of Sedation by Esketamine and Sevoflurane for Short Ophthalmological Procedure in Children

To see complete record on, please visit this link

Id: NCT05011214

Organisation Name: Eye & ENT Hospital of Fudan University

Overal Status: Enrolling by invitation

Start Date: September 20, 2021

Last Update: April 5, 2022

Lead Sponsor: Eye & ENT Hospital of Fudan University

Brief Summary: Pediatric diseases,including congenital cataract,,corneal injury,corneal ulcer, usually need suture removal and ophthalmic examination after Surgery for several days. Unfortunately, it remains a great challenge to achieve successful sedation due to children's noncooperation. Sevoflurane is one of the most often used anesthesia agents to provide deep sedation. Although sevoflurane has been used for pediatric anesthesia with successful keep spontaneous breathing without intubation, it should be noted that sevoflurane often results in air pollution under the open airway background and postoperative agitation.

Esketamine is the S (+) isomer of ketamine, which produces a dissociated state with minimal risk of airway compromise or apnea. It has enhanced analgesic potency and faster elimination compared to ketamine. However, it may also cause delirium during the recovery time. Based on these experiences on ketamine, we compared the effectiveness of esketamine and sevoflurane for short ophthalmological procedure in pediatric patients.

  • Sevoflurane

Total execution time in seconds: 0.29704999923706