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Ketamine Clinical Trials

Evaluation of Non-opioid Balanced General Anesthesia in Cardiac Surgery With Extracorporeal Circulation: a Randomized, Controlled, Multicenter Superiority Trial

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Id: NCT04886453

Organisation Name: Centre Hospitalier Universitaire Dijon

Overal Status: Recruiting

Start Date: August 30, 2021

Last Update: October 1, 2021

Lead Sponsor: Centre Hospitalier Universitaire Dijon

Brief Summary: Opioid-free anesthesia (OFA) is a general anesthesia based on the use of hypnotics and non-opioid analgesics (lidocaine, ketamine, dexamethasone, esmolol). This technique has been used for the past 10 years, during which randomized and non-randomized studies have demonstrated a number of positive effects on cardiac function:

better analgesia and decreased postoperative morphine consumption,
better respiratory function,
better hemodynamic stability,
better postoperative cognitive function.

The hypothesis of the present study is that the use of OFA during cardiac surgery is associated with:

Improved intraoperative hemodynamic stability
A decrease in the incidence of postoperative complications
A reduction in intensive care and hospital length of stay

  • Opioid-free Anesthesia
  • Cardiac Surgery

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