Ketamine molecule:

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Ketamine Clinical Trials

Reward Emotion Learning and Ketamine Study

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Id: NCT04850911

Organisation Name: University of Oxford

Overal Status: Not yet recruiting

Start Date: April 2021

Last Update: April 20, 2021

Lead Sponsor: University of Oxford

Brief Summary: Ketamine's efficacy as an antidepressant is now well established yet the mechanisms underlying its antidepressant effect are yet to be fully described. Work in the animal literature and research in humans is suggestive of specific effects on anhedonia and memory reconsolidation. In this study the investigators will further explore the effects of ketamine on learning and memory as well as measuring the associated changes at neural level in a sample of healthy volunteers. Participants will be assigned to receive ketamine or placebo and complete a set of tasks which will allow the investigators to quantify the effect of ketamine on learning about reward and punishment and memory for learned reward associations 24 hours after ketamine infusion. This study will help the investigators to understand the basis of ketamine's antidepressant effects and aid the development of new treatments for depression.

  • Depression
  • Major Depressive Disorder
  • Treatment Resistant Depression

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