Ketamine molecule:

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Ketamine Clinical Trials

Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Patient-controlled Analgesia After Scoliosis Correction Surgery: a Randomized, Double-blind, Placebo-controlled Trial

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Id: NCT04791059

Organisation Name: Peking University First Hospital

Overal Status: Completed

Start Date: April 9, 2021

Last Update: December 13, 2022

Lead Sponsor: Peking University First Hospital

Brief Summary: Scoliosis correction surgery is followed with severe pain. Patients after scoliosis correction surgery usually require high dose opioids and long duration analgesia, which may increase side effects and even drug tolerance. S-ketamine is the pure dextrorotatory enantiomer of ketamine with stronger analgesic effect and less side effects, but mental side effects is a major concern. Dexmedetomidine can be used as an analgesic supplement; it also improves sleep quality in postoperative patients. We hypothesize that low-dose ketamine and dexmedetomidine in combination with opioids may have synergistic effect in analgesia and reduce drug-related side effects. This study aims to explore the effect of low-dose of S-ketamine and dexmedetomidine in combination with opioids for postoperative patient-controlled intravenous analgesia in patients following scoliosis correction surgery.

  • Scoliosis Correction
  • Postoperative Analgesia
  • S-ketamine
  • Dexmedetomidine
  • Sufentanil

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