Ketamine molecule:

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Ketamine Clinical Trials


Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Patient-controlled Analgesia After Scoliosis Correction Surgery: a Randomized, Double-blind, Placebo-controlled Trial


To see complete record on clinicaltrials.gov, please visit this link

Id: NCT04791059

Organisation Name: Peking University First Hospital

Overal Status: Recruiting

Start Date: April 9, 2021

Last Update: April 19, 2021

Lead Sponsor: Peking University First Hospital

Brief Summary: Scoliosis correction surgery is followed with severe pain. Patients after scoliosis correction surgery usually require high dose opioids and long duration analgesia, which may increase side effects and even drug tolerance. S-ketamine is the pure dextrorotatory enantiomer of ketamine with stronger analgesic effect and less side effects, but mental side effects is a major concern. Dexmedetomidine can be used as an analgesic supplement; it also improves sleep quality in postoperative patients. We hypothesize that low-dose ketamine and dexmedetomidine in combination with opioids may have synergistic effect in analgesia and reduce drug-related side effects. This study aims to explore the effect of low-dose of S-ketamine and dexmedetomidine in combination with opioids for postoperative patient-controlled intravenous analgesia in patients following scoliosis correction surgery.

Conditions:
  • Scoliosis Correction
  • Postoperative Analgesia
  • S-ketamine
  • Dexmedetomidine
  • Sufentanil


Total execution time in seconds: 0.26434302330017