Ketamine Clinical Trials
The Best Dose of Esketamine for Day Surgery of Pediatric Circumcision
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Organisation Name: Yangzhou University
Overal Status: Completed
Start Date: January 15, 2021
Last Update: February 10, 2022
Lead Sponsor: Yangzhou University
Brief Summary: In recent years, daytime operation has been developed gradually in China. Circumcision in children is a common type of daytime operation. The nature of the operation and the object of the operation determine that the anesthetic drugs used should induce fast, wake up quickly and recover in a high quality.Conditions
Esketamine is an S-enantiomer of ketamine, which is newly marketed in China. Compared with ketamine, it has stronger effect on NMDA receptor, and its sedative effect is about twice as high. The occurrence frequency of respiratory depression and hypotension is lower than that of other anesthetics and analgesics, which can provide good analgesic and sedative effect for surgical anesthesia.
In clinical practice, ketamine combined with sevoflurane has been widely used in children's microsurgery, but there has been no report on Esketamine combined with sevoflurane anesthesia.
In order to find out the best combined dose, this paper compares the single administration of three different doses of esketamine combined with sevoflurane anesthesia in the circumcision of children.
Total execution time in seconds: 0.24492502212524