Ketamine molecule:

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Ketamine Clinical Trials

The Ketamine for Acute Postoperative Analgesia (KAPA) Trial

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Id: NCT04646694

Organisation Name: University Health Network, Toronto

Overal Status: Unknown status

Start Date: November 17, 2020

Last Update: November 30, 2020

Lead Sponsor: Michael Dinsmore

Brief Summary: Postoperative pain remains an important challenge for both patients and clinicians. Despite advances in pain management techniques, many patients continue to describe their pain as moderate to severe immediately after surgery. Poor postoperative pain control is associated with increased morbidity, functional impairment, and higher health care costs. While opioids currently represent the mainstay of treating surgical pain, their use is associated with significant side effects including respiratory depression, delayed recovery of bowel function as well as the potential for long-term use. Therefore, there is an urgent need to find new pain relievers with a safer side effect profiles. One such drug that has been receiving increasing attention is ketamine. Previous studies have focused on using intravenous ketamine postoperatively which requires a monitored setting but have ignored the oral form. By using the oral route of administration, ketamine could potentially be used by patients in a less resource-intensive manner with similar efficacy. Therefore, Investigators propose to conduct the Ketamine for Acute Postoperative Analgesia (KAPA) pilot study to examine the role of oral ketamine in improving recovery after spine surgery.

  • Postoperative Pain

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