Ketamine molecule:

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Ketamine Clinical Trials

The Effect and Contribution of a Perioperative Ketamine Infusion in an Established Enhanced Recovery Pathway

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Id: NCT04625283

Organisation Name: Vanderbilt University Medical Center

Overal Status: Enrolling by invitation

Start Date: April 12, 2021

Last Update: February 1, 2023

Lead Sponsor: Vanderbilt University Medical Center

Brief Summary: In order to effectively treat surgical pain with the least amount of opioids required, a multi-modal approach must include medications with different mechanisms of actions at alternative receptors. In light of the opioid epidemic, medical providers at Vanderbilt University Medical Center (VUMC) are strategically combining these medications in a bundled pain-regimen after surgery. These regimens have been shown to decrease opioid consumption, improve surgical outcomes, and reduce hospital stays, thus coining the term 'enhanced recovery pathway'. The combination of these medications has an indisputable synergistic effect. However, it is unknown how each medication contributes individually to the overall efficacy of the pathway. This study will examine the effects of ketamine, within the constructs of a multimodal pain regimen, on a) length of stay, b) opioid consumption, c) pain scores, and d) surgical outcomes after major abdominal surgery.

  • Opioid Use
  • Enhanced Recovery After Surgery
  • Anesthesia
  • Ketamine
  • Pain, Postoperative

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