Ketamine molecule:

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Ketamine Clinical Trials

Neuroprotection During Open Heart Surgery Propofol Versus Ketofol

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Id: NCT04486690

Organisation Name: Mansoura University

Overal Status: Completed

Start Date: July 1, 2016

Last Update: July 24, 2020

Lead Sponsor: ghada fouad

Brief Summary: Millions of individuals with coronary artery, or valvular heart disease have been given a new chance at life by heart surgery, but the potential for neurological injury is a great risk .Neural complications - including neurocognitive dysfunction and ischemic complications are complications of cardiac surgery that can restrict the improved quality of life.

Propofol is one of the most popular agents used for induction of anesthesia. propofol reduces cerebral blood flow but maintains coupling with cerebral metabolic rate for oxygen and decreases intracranial pressure, allowing optimal intraoperative conditions.

Ketamine is a non-competitive antagonist of NMDA receptors that has well documented neuroprotective effects against ischemic brain injury and glutamate-induced brain injury. ketamine has neuroprotective effects against oxygen-glucose deprivation injury

  • Open Heart Surgery

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