Ketamine molecule:

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Ketamine Clinical Trials

University of Iowa Interventional Psychiatry Service Patient Registry

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Id: NCT04480918

Organisation Name: University of Iowa

Overal Status: Recruiting

Start Date: November 2, 2020

Last Update: April 21, 2022

Lead Sponsor: Mark Niciu

Brief Summary: The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD). These treatments include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), racemic ketamine infusion and intranasal esketamine insufflation. The investigators will obtain various indicators, or biomarkers, of a depressed individuals' state before, during, and/or after these treatments. Such biomarkers include neurobehavioral testing, neuroimaging, electroencephalography, cognitive testing, vocal recordings, epi/genetic testing, and autonomic nervous system measures (i.e. "fight-or-flight" response). The results obtained from this study may provide novel antidepressant treatment response biomarkers, with the future goal of targeting a given treatment to an individual patient ("personalized medicine").

  • Treatment Resistant Depression
  • Major Depressive Episode
  • Major Depression
  • Major Depressive Disorder
  • Bipolar Disorder
  • Bipolar Depression
  • Obsessive-Compulsive Disorder

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