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Ketamine Clinical Trials

Opioid-Free Intravenous Anesthesia for Patients With Joint Hypermobility Syndrome Undergoing Craneo-Cervical Fixation: A Case-series Study Focused on Anti-hyperalgesic Approach

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Id: NCT04437589

Organisation Name: Servei Central d' Anestesiologia

Overal Status: Completed

Start Date: September 6, 2018

Last Update: July 10, 2020

Lead Sponsor: Servei Central d' Anestesiologia

Brief Summary: Cranio-cervical instability (CCI) has been well identified in diseases regarding connective tissue, such as Ehlers-Danlos Syndrome/Hipermobility Type (EDS-HT). These patients frequently suffer from severe widespread pain with very difficult management and control. Chronic neuroinflamation, opioid-induced hyperalgesia, and central sensitization phenomena may explain this complex painful condition. A retrospective, observational, consecutive case series study is designed to determine if opioid-free anesthetic management shows a reduction in postoperative pain and opioid rescues needs in comparison with opioid-based anesthesia management for patients with EDS-HT undergoing crano-cervical fixation.

  • Ehlers-Danlos Syndrome
  • Craniocervical Syndrome

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