Ketamine molecule:

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Ketamine Clinical Trials

Effect of Esketamine on Perioperative Depressive Symptoms in Patients Undergoing Major Surgery

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Id: NCT04425473

Organisation Name: Beijing Tiantan Hospital

Overal Status: Recruiting

Start Date: February 19, 2021

Last Update: March 2, 2021

Lead Sponsor: Beijing Tiantan Hospital

Brief Summary: Perioperative depressive symptoms (PDS) are common in population undergoing surgery, and this would be sharpened especially for complicated, high-risk major surgery. However, None of treatments could resolve this clinical problem during limited perioperative period. The remarkable effects of ketamine on treatment resistant depression have been verified by several clinical trials and the enantiomer S-ketamine (esketamine) showed similar antidepressant efficacy with better safety in recent studies. The efficacy and safety of esketamine administrated intra-operatively for PDS will be verified in this study. Other secondary outcomes such as anxiety, postoperative pain and psychiatric symptoms will also be investigated.

  • Depressive Symptoms
  • Esketamine
  • Perioperative Complication
  • Major Surgery

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