Ketamine molecule:

Image from PubChem

Ketamine Clinical Trials

Low Dose Ketamine Infusion for Postoperative Analgesia After Total Knee Arthroplasty: Optimum Dose to Reduce Morphine Consumption

To see complete record on, please visit this link

Id: NCT04085588

Organisation Name: Mustafa Kemal University

Overal Status: Completed

Start Date: April 15, 2019

Last Update: September 14, 2021

Lead Sponsor: Mustafa Kemal University

Brief Summary: This study evaluates continous infusion of low-dose ketamine during intraoperative and postoperative periods at three different doses to provide postoperative analgesia in total knee arthroplasty cases. Patients enrolled randomly into one of 2, 4, 6 μg / kg / min perioperative ketamine groups. All groups were given spinal anesthesia and intravenous patient controlled anesthesia. Ketamine was started when sensorial block reached T10 dermatome level before the skin incision. By the end of the operation, in all groups, ketamine infusions were reduced by half doses. Intravenous patient-controlled analgesia device was set to 2 mg bolus morphine with no basal infusion for 48 hours during the postoperative period.

  • Postoperative Pain

Total execution time in seconds: 0.22380900382996