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Ketamine Clinical Trials

Treatment of Patients With Morphine or/and Ketamine During Out-of-hospital Cardiac Pulmonary Resuscitation

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Id: NCT04009759

Organisation Name: University Hospital, Akershus

Overal Status: Not yet recruiting

Start Date: January 1, 2020

Last Update: July 5, 2019

Lead Sponsor: University Hospital, Akershus

Brief Summary: Preclinical studies demonstrate that opioids can preserve cellular integrity status during acute hypoxia in many organs and tissues including: intestine, skeletal muscle, myocardium and brain. Morphine has been shown to significantly increase the survival of mice and rats in acute hypoxia conditions. In the experimental model with rats exposed to hypoxic gas (5% oxygen, 95% N2) for 70 min, all seven rats in the naloxone pre-treated group died at the end of the experiments while only one out of seven rats died in the Morphine (5 mg/kg) pretreated group, and five from the seven rats died in the control group. In the experiments where the rats were exposed to 8 min anoxia, pre-treatment with Morphine (5mg/kg), or Ketamine (40 mg/kg), resulted in higher survival in both groups as compared to the control group (data not yet published). No publications looking at the survival rate in animals with treatment by Morphine before cardiac arrest have been published yet. Meanwhile, two recent retrospective studies demonstrated that patients who were treated with opioids before or during cardiac arrest had a statistically significantly higher survival rate and much better neurological outcome compared to untreated patients. As it is not possible to apply cardiac arrest to animal without any anaesthesia (main limitation of all experimental models of cardiac arrest), the sympathomimetic effects and possible neuroprotective features of Ketamine should be tested in patients with cardiac arrest. Additional topic for possible clinical research of Ketamine as well as Morphine could be their analgesic effects as vigorous thoracic compression with possible trauma of the ribs may lead to severe pain and stress related negative body responses in patients surviving CPR.

  • Cardiac Arrest

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