Ketamine molecule:

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Ketamine Clinical Trials


The Role of HNKs in the Antidepressant Effect of Ketamine


To see complete record on clinicaltrials.gov, please visit this link

Id: NCT03977675

Organisation Name: Columbia University

Overal Status: Recruiting

Start Date: May 15, 2019

Last Update: July 10, 2020

Lead Sponsor: Columbia University

Brief Summary: The objective of the proposed study is to examine the relationship between serum concentrations of HNK and changes in the Hamilton Depression Rating Scale (HDRS), Beck Depression Inventory (BDI), and the Profile of Mood States (POMS), as well as glutamatergic/GABAergic response. To achieve these aims the investigators propose a double-blind, uncontrolled (no placebo, no healthy control subjects) study with several different doses of ketamine. The investigators will conduct MRI scans to measure Glu and GABA before and during the ketamine treatment.

Conditions:
  • Major Depressive Disorder


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