Ketamine molecule:

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Ketamine Clinical Trials

Ketamine Versus Midazolam for Prehospital Agitation

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Id: NCT03554915

Organisation Name: Hennepin Healthcare Research Institute

Overal Status: Completed

Start Date: August 1, 2017

Last Update: April 5, 2019

Lead Sponsor: Hennepin Healthcare Research Institute

Brief Summary: This research study is being done to figure out the best approach to treatment of pre-hospital agitation. It will compare two tiered dosing treatment protocols, one ketamine-based and one midazolam-based. Agitation is a state of extreme emotional disturbance where patients can become physically aggressive or violent, endangering themselves and those who are caring for them. Often chemical substances or severe mental illness are involved in this level of agitation. Specifically, the investigators are interested in studying agitation that is treated in the prehospital setting by paramedics. This study's hypothesis is a ketamine-based protocol will achieve a faster time to adequate sedation than a midazolam-based protocol for treatment of agitation in the prehospital environment. This study will observe the natural history of an emergency medical services standard operating procedure change from a ketamine-based protocol to a midazolam-based protocol.

  • Agitation

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