Ketamine molecule:

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Ketamine Clinical Trials

Substance Misuse To Psychosis for Ketamine (SToP-K) -Who is At Risk? A Case-Control Study in Ketamine and Non-Ketamine-Using Substance Abusers

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Id: NCT03485339

Organisation Name: The University of Hong Kong

Overal Status: Completed

Start Date: June 12, 2018

Last Update: July 31, 2020

Lead Sponsor: The University of Hong Kong

Brief Summary: Evidence suggests that repeated or chronic ketamine use, as compared to acute ketamine users, posed a higher clinical risk of developing psychotic disorders, potentially related to the underlying chronic N-methyl-D-aspartate receptor (NMDAR) dysfunction, and a higher risk of suffering from schizophrenia particularly in those genetically susceptible, or genetically predisposed ketamine abusers. With ketamine infusion rises as a emerging hope as an acute treatment for depression and suicidality under the shadow of unknown longer term psychotomimetic effects peculiarly amongst repeated or chronic use, the current case-control study aims to investigate: a) if repeated or chronic ketamine use is associated with an increased risk of psychosis by comparing those ketamine abusers with and without psychosis, and to those non-ketamine-using drug abusers with psychosis; and b) if genetic predisposition from single nucleotide polymorphisms are associated with risk of psychosis in ketamine abusers.

  • Ketamine Abuse
  • Psychotic Disorders
  • Substance Use Disorders
  • Schizophrenia
  • Genetic Predisposition

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