Ketamine molecule:

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Ketamine Clinical Trials

Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine

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Id: NCT03096444

Organisation Name: University of Miami

Overal Status: Terminated

Start Date: May 23, 2017

Last Update: July 2, 2019

Lead Sponsor: Gil Yosipovitch

Brief Summary: The purpose of this study is to examine the antipruritic efficacy of topical ketamine, amitriptyline, lidocaine, and a tri-combination of ketamine, amitriptyline and lidocaine (hereafter referred to as "KeAmLi") using non-histaminergic itch provocations in healthy volunteers. The primary outcome is itch reduction (AUC) between the vehicle and active treatment (KeAmLi-combo). Secondary outcomes include modality-specific analgesic properties of the topically applied ketamine, amitriptyline, lidocaine, and KeAmLi-combo to controlled quantitative thermal and mechanical stimuli, which can improve our understanding of the mechanism of action of these substances in the context of topical therapy.

  • Pruritus

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