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Ketamine Clinical Trials


The Neural Mechanisms of Anesthesia and Human Consciousness (Part 6)


To see complete record on clinicaltrials.gov, please visit this link

Id: NCT02624401

Organisation Name: University of Turku

Overal Status: Completed

Start Date: January 2016

Last Update: March 27, 2017

Lead Sponsor: University of Turku

Brief Summary: Positron Emission Tomography (PET), Magnetic Resonance Imaging (MRI) and electroencephalography (EEG) studies will be carried out to reveal the neural correlates of consciousness. Consciousness of the subjects will be manipulated with anesthetic agents dexmedetomidine, propofol, S-ketamine and sevoflurane. One-hundred-and-sixty (160) healthy male subjects will be recruited to receive EC50 concentration of the anesthetic (40 dexmedetomidine, 40 propofol, 20 S-ketamine, 40 sevoflurane) or placebo (20) while being imaged for cerebral metabolic rate of glucose (CMRglu). Also genetic, immunological and metabolomics samples will be taken and analysed to find possible genetic factors explaining the variability in drug response and to find chemical fingerprints of acute drug effect.

Conditions:
  • Anesthesia
  • Unconsciousness


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