Ketamine molecule:

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Ketamine Clinical Trials

Efficacy and Safety of Repeated Intravenous Subanesthetic Ketamine Infusions Among Veterans With Treatment Resistant Depression Comorbid With Chronic Post-Traumatic Stress Disorder: A Proof-of-concept Study

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Id: NCT02577250

Organisation Name: Minneapolis Veterans Affairs Medical Center

Overal Status: Completed

Start Date: May 2015

Last Update: May 14, 2019

Lead Sponsor: Minneapolis Veterans Affairs Medical Center

Brief Summary: The relationship between depression and trauma is well established. Co-occuring depression and post-traumatic stress disorder (PTSD) are associated with more severe symptoms and lower levels of functioning. Veterans with both depression and PTSD have been shown to be at much higher risk of suicide than individuals with only one of these disorders. Ketamine has been shown to have rapid antidepressant effects and also therapeutic action over PTSD symptoms. The purpose of this study is to see whether ketamine, when given as repeated infusions, can produce quick and sustained improvement in depression and PTSD symptoms for individuals who have not had their symptoms effectively treated by current treatments.

  • Depressive Disorder, Treatment-Resistant
  • Stress Disorders, Post-Traumatic

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