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Ketamine Clinical Trials

Effects of Low Doses of Ketamine on Postoperative Quality of Recovery After Total Intravenous Anesthesia

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Id: NCT02571153

Organisation Name: Pontificia Universidade Catolica de Sao Paulo

Overal Status: Completed

Start Date: September 2015

Last Update: March 6, 2017

Lead Sponsor: Pontificia Universidade Catolica de Sao Paulo

Brief Summary: There are evidences that intraoperative administration of low doses of ketamine may contribute to control the postoperative pain by acting on the N-methyl-D-aspartate (NMDA) channel, reducing the effects related to the tolerance and hyperalgesia induced by opioids. This study aims to evaluate the effects of administration of this agent not only as an analgesic but also its role in the quality of recovery from anesthesia, which includes observation of emotional, psychological and physical aspects. Patients who were scheduled to undergo total intravenous anesthesia (TIVA) for laparoscopic cholecystectomy will be enrolled in this clinical study. After induction of anesthesia, patients will receive one of three solutions according to the randomly selected group: ketamine 0,2 mg/kg; ketamine 0,4 mg/kg or saline. In the recovery room and on the ward, data related to the presence of pain, analgesic consumption, the incidence of nausea and vomiting, dizziness or hallucinations will be recorded. The next day, the quality of recovery will be evaluated by application of the questionnaire QoR40 (Quality of Recovery Questionnaire-40).

• Postoperative Pain
• Postoperative Nausea and Vomiting