Ketamine molecule:

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Ketamine Clinical Trials

Low-dose Ketamine Versus Morphine for Severe Painful Sickle Cell Crises in Children at Mulago Hospital: A Randomised Controlled Trial

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Id: NCT02434939

Organisation Name: Makerere University

Overal Status: Completed

Start Date: June 2015

Last Update: August 3, 2016

Lead Sponsor: Makerere University

Brief Summary: This clinical trial will inform of the role of Low dose ketamine in the acute treatment of severe painful sickle cell crisis in children in a day-case sickle cell centre. The primary aim is to determine whether Low dose ketamine is non inferior to morphine in the management of acute painful sickle cell crises. The specific objectives will be to determine the maximal change in NRS pain score following administration of ketamine and to examine the safety profile of ketamine compared to morphine in this population.

The investigators hypothesize that low dose ketamine will result in similar effective pain control as morphine alone and will not be associated with an increase in adverse events.

  • Sickle Cell Crisis
  • Acute Pain

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