Ketamine Clinical Trials
Randomized Controlled Trial of Repeated-Dose Intravenous Ketamine for PTSD
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Id: NCT02397889
Organisation Name: Icahn School of Medicine at Mount Sinai
Overal Status: Completed
Start Date: May 18, 2015
Last Update: March 11, 2021
Lead Sponsor: Icahn School of Medicine at Mount Sinai
Brief Summary: The purpose of this study is to study new ways to treat post-traumatic stress disorder (PTSD). Current treatments for PTSD do not work for everyone and it can take time to determine whether a person responds to a chosen treatment. The purpose of this study is to see whether ketamine, when given repeatedly intravenously can produce a quick and persistent improvement in PTSD symptoms. At higher doses, ketamine has been used for many years as an anesthetic for medical procedures, and at lower doses may be an effective treatment in patients with major depression and PTSD. Ketamine given for PTSD is investigational, which means that the FDA has not yet approved the drug for treating this condition. In this study, the effects of ketamine will be compared to those of midazolam. Midazolam has similar acute anesthetic effects compared to ketamine but has not been shown to treat or alleviate any symptoms of PTSD. This makes midazolam an appropriate substance to gauge whether ketamine can treat or alleviate PTSD symptoms thereby acting as what we call an active control.
Conditions:
- Posttraumatic Stress Disorder (PTSD)
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