Ketamine molecule:

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Ketamine Clinical Trials

Intravenous Sub-anesthetic Ketamine Treatment in Treatment-Resistant Depression

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Id: NCT02360280

Organisation Name: VA Office of Research and Development

Overal Status: Completed

Start Date: April 1, 2015

Last Update: June 7, 2022

Lead Sponsor: VA Office of Research and Development

Brief Summary: About one-third of depressed patients will not get better after multiple antidepressant treatments. This situation put a high burden on patients with depression due to worsening quality of life and increasing health care costs. Difficult-to-treat depression might be even worse among Veterans given that the frequency of depressive symptoms is 2 to 5 times higher than among the general US population. A breakthrough discovery happened in recent years when investigators found that one infusion from an old anesthetic named ketamine showed high efficacy and rapid antidepressant effect (sometimes within hours) but lasted only up to a week. The investigators propose to study if multiple infusions of ketamine can provide greater and longer antidepressant effects than one infusion. If that is the case, multiple infusions could be an alternative to relieve depressive symptoms that do not response to multiple antidepressant drugs.

  • Treatment-resistant Depression

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