Ketamine molecule:

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Ketamine Clinical Trials

Sedation Strategy and Cognitive Outcome After Critical Illness in Early Childhood

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Id: NCT02225041

Organisation Name: University of Pennsylvania

Overal Status: Completed

Start Date: August 2014

Last Update: June 18, 2019

Lead Sponsor: University of Pennsylvania

Brief Summary: The purpose of this study is to determine the relationships between sedative exposure during pediatric critical illness and long-term neurocognitive outcomes. We will test for drug- and dose-dependent relationships between sedative exposure and neurocognitive outcomes along the early developmental spectrum and will control for baseline and environmental factors, as well as the severity and course of illness.


Greater exposure to benzodiazepines and/or ketamine will be associated with lower IQ even when controlling for severity of illness, hospital course, and baseline factors. In addition, benzodiazepines and/or ketamine will negatively affect other aspects of neurocognitive function.
Younger children exposed to benzodiazepines and/or ketamine will have worse neurocognitive outcomes than older children with similar sedative exposure and severity of illness.

  • Intellectual Disability
  • Perceptual Disorders
  • Memory Disorders

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