Ketamine molecule:

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Ketamine Clinical Trials

Effects of Ketamine Treatment on Suicidal Ideation, Drug-resistant Major Depression, and Negative Emotional Experience. Clinical and fMRI Study

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Id: NCT02037503

Organisation Name: Tel-Aviv Sourasky Medical Center

Overal Status: Unknown status

Start Date: January 2014

Last Update: April 2, 2020

Lead Sponsor: Tel-Aviv Sourasky Medical Center

Brief Summary: Suicide attempts are a serious concern worldwide. Currently, existing drugs take about three weeks to show effect on suicidal thoughts and drives. Recent evidence suggests that intravenous Ketamine exerts a rapid effect in suicidal patients, even after a single injection. We aim to examine whether oral Ketamine is a safe and effective treatment in suicidal patients. Following a suicide attempt, patients will be randomized into a group that will be given Ketamine for 21 days and one that will receive placebo, and assessed using questionnaires and brain scans. We expect early improvements in suicide scales in the Ketamine group.

As a secondary goal, this study will use IV ketamine in order to access the extent to which the experience of the embodied self mediate different levels of "embodied emotion". A better understanding of these relations will assist in unveiling the cognitive mechanism underlying the therapeutic effect of ketamine

  • Suicidal Ideation
  • Major Depressive Disorder
  • Healthy Participants

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