Ketamine molecule:

Image from PubChem

Ketamine Clinical Trials


The Effects of Subanesthetic Ketamine on Respiratory Stimulation and Transpulmonary Pressures in Mechanically Ventilated Critically Ill Patients


To see complete record on clinicaltrials.gov, please visit this link

Id: NCT01969227

Organisation Name: Massachusetts General Hospital

Overal Status: Active, not recruiting

Start Date: January 2014

Last Update: November 10, 2020

Lead Sponsor: Massachusetts General Hospital

Brief Summary: Impairment of airway patency is a common cause of extubation failure and opioids and hypnotics can adversely affect airway patency. Ketamine, a noncompetitive antagonist of N-methyl-D-aspartate (NMDA), unlike other anesthetics activates respiratory effort and promotes bronchodilation. At subanesthetic plasma concentration, ketamine reduces both opioid and propofol requirements.

The purpose of this pharmaco-physiological interaction trial is to evaluate the effects of ketamine on breathing and electroencephalography in mechanically ventilated patients.

Conditions:
  • Mechanical Ventilation
  • Airway Patency
  • Respiratory Depression


Total execution time in seconds: 0.19751191139221