Ketamine molecule:

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Ketamine Clinical Trials

The Effects of Subanesthetic Ketamine on Respiratory Stimulation and Transpulmonary Pressures in Mechanically Ventilated Critically Ill Patients

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Id: NCT01969227

Organisation Name: Massachusetts General Hospital

Overal Status: Active, not recruiting

Start Date: January 2014

Last Update: November 10, 2022

Lead Sponsor: Massachusetts General Hospital

Brief Summary: Impairment of airway patency is a common cause of extubation failure and opioids and hypnotics can adversely affect airway patency. Ketamine, a noncompetitive antagonist of N-methyl-D-aspartate (NMDA), unlike other anesthetics activates respiratory effort and promotes bronchodilation. At subanesthetic plasma concentration, ketamine reduces both opioid and propofol requirements.

The purpose of this pharmaco-physiological interaction trial is to evaluate the effects of ketamine on breathing and electroencephalography in mechanically ventilated patients.

  • Mechanical Ventilation
  • Airway Patency
  • Respiratory Depression

Total execution time in seconds: 0.59426498413086