Ketamine molecule:

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Ketamine Clinical Trials

The Effect of Ketamine on Reducing Cue Reactivity in Cocaine Users

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Id: NCT01790490

Organisation Name: New York State Psychiatric Institute

Overal Status: Completed

Start Date: February 2011

Last Update: April 30, 2019

Lead Sponsor: New York State Psychiatric Institute

Brief Summary: Cocaine dependence involves problematic neuroadaptations, such as heightened reactivity to cocaine cues, that may be responsive to pharmacological modulation of glutamatergic circuits. Despite promising preclinical findings with n-methyl-d-aspartate receptor (NMDAr) modulators, studies with human subjects have been unsuccessful to date. The purpose of this investigation is to examine the effects of the NMDAr antagonist ketamine, recently found to have potent therapeutic effects in humans, on cue-induced craving and impaired motivation for quitting cocaine in cocaine dependent participants, 24-hours post-infusion.

  • Cocaine Dependence

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