Ketamine molecule:

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Ketamine Clinical Trials

Combination of Anticholinergic and Glutamatergic Effects in Treatment-resistant Major Depressive Disorder. A Pilot Study

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Id: NCT01613820

Organisation Name: Massachusetts General Hospital

Overal Status: Withdrawn

Start Date: September 2015

Last Update: February 19, 2018

Lead Sponsor: Massachusetts General Hospital

Brief Summary: Ketamine infusions resulted in an acute reduction in global depression scores and in severity of suicidal ideation. Scopolamine infusions produced also a significant improvement in depression that was sustained over time.

We therefore plan to investigate the feasibility and efficacy of open-label repeated intravenous administration of ketamine and scopolamine combined in this population of severely depressed, treatment-resistant patients. The results from this study could lead to the development of new strategies for the treatment of patients with TRD.

  • Major Depressive Disorder

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