Ketamine molecule:

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Ketamine Clinical Trials

Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone

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Id: NCT01594047

Organisation Name: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Overal Status: Unknown status

Start Date: December 2009

Last Update: May 16, 2012

Lead Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Brief Summary: Background: In perioperative period inhibition of N-Methyl-D-Aspartate receptor prevents opioid-induced hyperalgesia and reduce postoperative opioid requirement after abdominal surgery. Methadone is both a µ-opioid receptor agonist like Morphine and a N-Methyl-D-Aspartate antagonist. Study Aim. To evaluate the efficacy of intraoperative Ketamine and postoperative Methadone analgesia in preventing opioid-induced hyperalgesia after abdominal surgery.

  • Post Operative Pain
  • Hyperalgesia

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