Ketamine molecule:

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Ketamine Clinical Trials

Phase 4 Study of Prevention of Persistent Postsurgical Pain After Thoracotomy Using Ketamine

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Id: NCT01243801

Organisation Name: Hospital Clinic of Barcelona

Overal Status: Completed

Start Date: September 2008

Last Update: March 23, 2015

Lead Sponsor: Hospital Clinic of Barcelona

Brief Summary: Postthoracotomy acute pain is followed by persistent postsurgical pain in 20-30% of the patients, defined as pain that lasts more than 3-6 months after surgery. Acute pain and hyperalgesia around the surgical wound are some of the risk factors associated to the development of chronic pain. Ketamine, as a NMDA antagonist mainly at spinal level, might reduce periincisional hyperalgesia and persistent postsurgical pain after thoracotomy. Therefore, the investigators hypothesized that continuous ketamine infusion at subanesthetic dose would potentiate epidural ropivacaine and fentanyl-induced analgesia after thoracotomy, reduce periincisional hyperalgesia and long-term postoperative pain. To test these hypothesis, the investigators administered a low dose of intravenous ketamine or epidural ketamine or placebo to patients who received an epidural infusion of ropivacaine and fentanyl for postthoracotomy pain.

  • Persistent Pain
  • Postoperative Hyperalgesia

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