Ketamine molecule:

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Ketamine Clinical Trials


Neurophysiology and Pharmacology of Cough Reflex Hypersensitivity


To see complete record on clinicaltrials.gov, please visit this link

Id: NCT00858624

Organisation Name: University of Manchester

Overal Status: Completed

Start Date: February 2008

Last Update: June 19, 2013

Lead Sponsor: Jacky Smith

Brief Summary: A cough lasting more than 2 months is known as a chronic cough, affecting 12-23% of the adult non-smoking population. Chronic cough has many associated complications including incontinence, muscular chest pains, blackouts and depression. Current treatment is often ineffective in these patients. To develop new medications the investigators need to understand more about the mechanisms that can lead to excessive coughing.

This study plans to compare a group of 12 healthy volunteers and 12 patients with a chronic cough. The investigators hypothesise that that chronic cough patients have a more sensitive cough reflex as a result central nervous system hyper-excitability (central sensitisation). The investigators will measure cough reflex sensitivity before and after administration of ketamine, a medication that blocks an important receptor in the central nervous system.

Conditions:
  • Chronic Cough


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