Ketamine molecule:

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Ketamine Clinical Trials


Ketamine Pharmacokinetics in Children Undergoing Cardiac Surgery


To see complete record on clinicaltrials.gov, please visit this link

Id: NCT00598195

Organisation Name: Arkansas Children's Hospital Research Institute

Overal Status: Completed

Start Date: June 2006

Last Update: February 27, 2013

Lead Sponsor: Arkansas Children's Hospital Research Institute

Brief Summary: What are the pharmacokinetics of ketamine in infants and children requiring ketamine for induction of anesthesia for cardiac surgery that requires CPB? Specific Aim 1: To determine the pharmacokinetic parameters of a single intravenous bolus dose of ketamine in infants and children undergoing cardiac surgery with and without CPB (cardio-pulmonary bypass).

Specific Aim 2: To describe the disposition of ketamine's primary active metabolite, norketamine,following a single intravenous bolus dose of ketamine in infants and children undergoing cardiac surgery with and without CPB.

Specific Aim 3: To determine the relationship between ketamine and norketamine pharmacokinetic parameters and age as well as CPB time.

Conditions:
  • C.Surgical Procedure; Cardiac


Total execution time in seconds: 0.90498805046082