Ketamine Clinical Trials
A Randomized Trial of Etomidate Versus Midazolam for Intubation of Patients With Sepsis.
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Organisation Name: Advocate Hospital System
Overal Status: Completed
Start Date: October 2007
Last Update: April 11, 2012
Lead Sponsor: Advocate Hospital System
Brief Summary: The primary aim is to determine the difference in hospital length of stay between septic patients given etomidate and those given midazolam for induction during rapid sequence intubation (RSI) in the emergency department. To achieve this aim we plan to perform a prospective randomized trial measuring the length of stay of patients meeting sepsis criteria and requiring intubation. The investigators will compare in-hospital mortality rates between patients given etomidate and patients given midazolam for induction. In addition to hospital length of stay, secondary endpoints between the two groups will include length of stay in the intensive care unit, death within 48 hours of admission, and total number of days intubated.Conditions
In adult patients presenting to the emergency department with sepsis and requiring rapid sequence intubation, the length of stay of patients given etomidate will be greater than that of patients given the alternative agent midazolam for induction.
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