Ketamine molecule:

Image from PubChem

Ketamine Clinical Trials


Effect of Ketamine (Ketalar) on Intracranial Pressure


To see complete record on clinicaltrials.gov, please visit this link

Id: NCT00437814

Organisation Name: Rambam Health Care Campus

Overal Status: Unknown status

Start Date: September 2005

Last Update: February 21, 2007

Lead Sponsor: Rambam Health Care Campus

Brief Summary: Objectives: Ketamine is an effective, short-acting anesthetic drug, which does not decrease blood pressure. It is widely stated that Ketamine increases intracranial pressure (ICP), which prevents its use in many emergency situations, specifically in patients with traumatic brain injury (TBI) and with increased ICP. Based on previous clinical experience, we hypothesized that Ketamine decreases - rather than increases - ICP.

Methods: Prospective, controlled, clinical trial. Children with ICP monitoring will receive a single Ketamine dose (1-1.5 mg/kg) either for increased ICP and/or before a potentially distressing activity. Hemodynamic variables, ICP and cerebral perfusion pressure (CPP) will be recorded 1 minute before and every minute for 10 minutes following Ketamine administration (Before/after design).

Conditions:
  • Traumatic Brain Injury
  • Intracranial Hypertension


Total execution time in seconds: 0.20918798446655