Ketamine molecule:

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Ketamine Clinical Trials

Efficacy of a Polyamine-free Diet Associated or Not With Ketamine on Early and Late Hyperalgesia After Breast Cancer Surgery

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Id: NCT00304850

Organisation Name: University Hospital, Bordeaux

Overal Status: Completed

Start Date: March 2006

Last Update: December 29, 2009

Lead Sponsor: University Hospital, Bordeaux

Brief Summary: After surgery, sensitization and hyperexcitability of central nervous system result in acute and long lasting postoperative pain. It has been shown that N-methyl-D-aspartate (NMDA) receptors antagonist (such as ketamine) prevent this adverse neuroplasticity and potentiate analgesic drugs efficacy. Polyamines (putrescine, spermidine, spermine) are essential components of cells functioning and are also known as allosteric modulators of NMDA receptors. In animal studies, polyamine-free diet has confirmed these antinociceptive properties. This research aims at evaluating anti hyperalgesic properties of polyamine-free diet in women operated on breast cancer versus kétamine

  • Breast Cancer
  • Surgery

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