Ketamine Clinical Trials
Effect of ketamine and brain stimulation on tinnitus loudness and distress
To see complete record on anzctr.org.au, please visit this link
Id: ACTRN12621000119897p
Organisation Name: Dirk De Ridder
Overal Status: Not yet recruiting
Start Date: 15/02/2021
Brief Summary: Tinnitus is a significant and growing health challenge globally, affecting individuals, their whanau, the wider community, and the healthcare system. Tinnitus, defined as the phantom perception of sound, is estimated to affect 6% of New Zealand’s total population aged 14 and over, with prevalence increasing alongside age. For 2-3% of individuals in the population, tinnitus leads to significant impairments in quality of life. Psychological comorbidities associated with tinnitus drive much of the morbidity, and result in significant loss of health and productivity. Commonly reported symptoms include cognitive dysfunction, annoyance, insomnia, anxiety, and depression. Additionally, tinnitus management is a significant financial burden: in New Zealand, the approximate annual costs of tinnitus are estimated to be $7.5 billion. This makes tinnitus an attractive target for improving health related quality of life. Bimodal approaches may offer significant value in treating tinnitus, by coupling plasticity generation to a means of directing the brain towards a more normal state.
Hypothesis: That low dose Ketamine, through effects on brain plasticity, may be able to catalyse transcranial electrical stimulation, to reduce tinnitus loudness, and/or distress.
The aim of the proposed study is to explore the effect over short term follow-up of ketamine and transcranial stimulation on tinnitus loudness and distress, in participants suffering from tinnitus, in a controlled trial.
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