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Ketamine Clinical Trials

Comparing blood concentrations of intravenous and nebulized sedatives and analgesics in patients who are on mechanical ventilation.

To see complete record on anzctr.org.au, please visit this link

Id: ACTRN12620001039976

Organisation Name: REDUCE Centre for Research Excellence - University of Queensland

Overal Status: Not yet recruiting

Start Date: 09/11/2020

Brief Summary: Pain and discomfort are commonly associated with all disease conditions especially in critical care. Despite pharmacological developments, the management of pain and discomfort remains suboptimal and often associated with complications. Administering the existing drugs via the inhaled route could achieve better concentration of the drug for effective pain relief and sedation while avoiding side effects. Previous studies have demonstrated safety and often efficacy of inhaled sedatives and pain relief. However, due to the absence of concentration data there is lack of dosing guidelines and hence leading to variable dosing which causes inadequate clinical effect.

This is a prospective, open labelled observational Pharmacokinetic (PK) (drug metabolism) study with the aim of describing the comparative concentrations of the single dose sedatives and pain relief agents between intravenous, through the vein and inhaled routes of drug delivery. Blood and urine samples will be studied to assess the concentrations of the sedative and pain relief. The following drugs will be observed: fentanyl, morphine, midazolam, clonidine, dexmedetomidine and ketamine.

It is hoped that the knowledge gained from this study will enable the development of dosing regimens for optimal inhaled sedative and pain relief therapy.

We plan to recruit at least 10 participants per drug for this study.

• Australia